Chandini Sreedharan was born on December 12 in Calicut, Kerala to Sreedharan Surendran (father) and Rajani Sreedharan (mother).
She has a younger brother (Gopal Sreedharan). She was brought up in America with a passion for dance and music.
Chandini Sreedharan was the winner of reality show Vivel Active Fair Big Break, a reality show aired on Surya TV in 2011. In 2013, she debuted with the Tamil movie Ainthu Ainthu Ainthu directed by Sasi. She played the female lead opposite Bharath. However, she was known as Mrithika in the film credits. Her second movie was in Telugu, Chakkiligintha directed by Vema Reddy. She played the female lead opposite Sumanth Ashwin. And, she was credited as Rehhana in this film.
Her third movie was in Malayalam, KL 10 Patthu directed by Muhsin Parari. She played the female lead opposite Unni Mukundan. This time, she decided to use her real name Chandini Sreedharan and plans to use the same in all industries in the future. Then she acted in the Malayalam movie Darvinte Parinamam directed by Jijo Antony. She played the female lead opposite to Prithviraj.